In our other run, we utilize honing and also poison.
5e does list poisons that do certain things, but the cost is prohibitively high. For example:
Drow Poison (Injury):
A poison typically made by drow, requiring a DC 13 Constitution saving throw or the target is poisoned for 1 hour, and possibly unconscious if the save fails by 5 or more.
Purple Worm Poison (Injury):
A potent poison requiring a DC 19 Constitution saving throw, dealing 42 (12d6) poison damage on a failed save, or half as much on a success.
Serpent Venom (Injury):
A common poison, requiring a DC 13 Constitution saving throw or the target is poisoned for 1 hour.
Poisoned condition: A poisoned creature has disadvantage on attack rolls and ability checks.
So they're great and their cost is hundreds of gold in some cases.
I am offering to share the three poison system based on cooking, tinkering, or alchemy skill.
The process is as follows: you forage while looking for specific plant species, I have 6 so far such as datura, oleander and hemlock. You will find some amount of it each time you forage successfully. A single forage is a variable amount of time but almost always guarantees you find something. When you find at least three components, you can make some number of doses of weapon grade poison that can be applied to slashing or piercing weapons. The poison is only expended if the weapon hits.
You can also make bait: 1 raton and three doses of poison that can be used on a creature if they eat it.
In any case they have various effects that are unknown to you and based on rolls:
1 roll based on your crafting/cooking/alchemy skill will determine the quality of the poison
6 separate rolls will determine the effects such as DC and including stun, unconsious, nausia, straight damage, poison, or other conditions. There is the potential for 3 stacking effects per batch of poison. 1 batch is say 10 uses and uses up 1 pound or 10 portions of each of 3 poisons.
This is still WIP, but if you're interested in foraging extra damage to enemies on first hit and not just from honing, then I can add it to your game. In this case, honing will be a necessary step for poisoning a weapon and this includes arrows, so they don't stack.
Otherwise you can continue to hone weapons and in addition arrows, in our run, a blade takes 30 minutes and an arrow takes 15 minutes. They both get +1 for hit and damage.